Florida State Road 780

A five-mile-long east–west street, State Road 780 is known as Fruitville Road by the residents of Sarasota, Florida. The western terminus is an intersection with Tamiami Trail (US 41/SR 45) in the downtown area. The eastern terminus is an interchange with Interstate 75 (SR 93) in Fruitville.

Historically, SR 780 continues eastward on Fruitville Road past the current terminus, through Fordville, before zigzagging through Old Myakka before becoming Clay Gully Road at the northern boundary of Myakka River State Park. Three miles east of Sandy, Clay Gully Road turns northward at the boundary between Sarasota County and DeSoto County, where it reaches the historic eastern terminus of SR 780, an intersection with SR 70 three miles (5 km) southeast of Edgeville. The part of former SR 780 east of I-75 became Sarasota County Road 780 in the early 1980s, after Florida Department of Transportation designated it a secondary State Road (and applied an "S-" prefix to the State Road 780 designation a decade earlier). This was part of a large set of redesignations that transformed the map of the State of Florida.

West of Washington Boulevard, Fruitville Road extends one mile (1.6 km) to the west of the end of SR 780, ending at an intersection with the Tamiami Trail (US 41-SR 45) in downtown Sarasota. Near the intersection (and along the Tamiami Trail) are concert halls, performance centers, and a museum.